Pharmacogenetics
  • Volunteer databases and relationships with medical practices in the community allow studies in both healthy and diseased populations.
  • Over 3,500 volunteers in database have collected genotype sample, and the majority have expressed interest in participating in future studies and remain in the community.
Genomic Information by CYP2D6 for all volunteers screened*
Ethnic Background Male Extensive Female Extensive Male Poor Female Poor
Caucasian 83% 87% 81% 89%
African American 12% 9% 11% 9%
Hispanic 3% 3% 4% 1%
Asian <1% 1% -- --
Other 2% -- 4% 1%
*Note: some subjects’ results not returned. ~16 URMs and 5 possible IMs not included.
*Note: similar summaries for CYP2C9 and CYP2C19 are available.

Genomic DNA Isolation and Molecular Genotyping analysis of Blood Samples for the purpose of Identifying Prospective Volunteers for Clinical Pharmacology

  • CYP450
  • CYP2D6
  • Transporters
  • Conjugators
  • ADAM
  • ALOX
  • &-nAChR
  • COX
  • D2, D3, D4
  • PMO
  • FMO
  • GH1
  • ONR
  • PDE
  • _-opioid Receptor

 
 
 
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